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KMID : 1161420190220080810
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Journal of Medicinal Food
2019 Volume.22 No. 8 p.810 ~ p.816
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Enteral Nutrition as a Growth Medium for Cultivable Commensal Bacteria and Its Effect on Their Quantity in the Stool of Children with Crohn's Disease
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Modrackova Nikol
Bunesova Vera
Vlkova Eva
Musilova Sarka
Mrvikova Iva
Bronsky Jiri
Copova Ivana
Hradsky Ondrej
Nevoral Jiri
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Abstract
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Current studies indicate a link between the intake of exclusive enteral nutrition (EEN) and the induction of complex changes in the intestinal microbiota, as well as the clinical improvement of Crohn's disease (CD). The first aim of this study was to test the ability of various commensal bacterial strains (n?=?19) such as bifidobacteria, lactobacilli, and Escherichia coli to grow on three different polymeric EN in vitro. Tested EN formulas were found to be suitable growth media for tested commensals. Furthermore, the counts of these bacteria and total counts of anaerobic bacteria in the fecal samples of children with CD (n?=?15) before and after 6 weeks of EEN diet administration were determined using cultivation on selective media. The counts of cultivable commensal bacteria in the fecal samples of CD children were not significantly affected by EEN. However, tested bacteria showed some individual shifts in counts before and after EEN therapy. Moreover, cultured bifidobacteria were found to be in reduced counts in CD children. Therefore, the application of bifidogenic prebiotic compounds to EN for CD patients might be considered.
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KEYWORD
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bifidobacteria, Escherichia coli, exclusive enteral nutrition, inflammatory bowel disease, lactobacilli, probiotics
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